Studies on Sulfonamides. I
نویسندگان
چکیده
منابع مشابه
Studies on Highly Soluble Azo Sulfonamides.
Since the early observations of Kellner (1936) and Fuller (1937), who demonstrated that p-aminobenzenesulfonamide (sulfanilamide) is formed in animal tissues when prontosill or prontosil soluble2 (neoprontosil3) is administered by mouth, and the studies by Domagk (1935), Colebrook and Kenney (1936), and Colebrook, Buttle, and O'Meara (1936), wherein they were unable to demonstrate an antibacter...
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We report the synthesis and characterization of the pyrrole sulfonamide as a new class of potential molecular receptors, including conformational analysis and molecular recognition studies for four pyrrole sulfonamide derivatives.
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Studies previously reported on the mode of action of sulfonamides on bacteria showed that the inhibition of respiratory enzymes of the bacteria caused a proportional inhibition of the growth of Streptococcus pyogenes and pneumococcus, type I. This conclusion was based on simultaneous measurements, at various time intervals, of the increase in the number of bacteria (and the mg of bacterial nitr...
متن کاملStudies on the Action of Sulfonamides on the Respira- Tion and Growth of Bacteria1 A. Factors Controlling the Inhibition by Sulfonamides of Carboxy-
In two previous reports, it was shown that cocarboxylase and p-aminobenzoic acid counteract the inhibitory effect of sulfathiazole on yeast and bacterial carboxylases. Whereas cocarboxylase brings about this effect without exercising any inhibitory action on carboxylase, p-aminobenzoic acid exercises the antagonistic action to sulfathiazole while maintaining a certain degree of inhibitory effec...
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Considerable investigation has been done as to whether or not a particular drug is effective for recovery of an animal after it has become exhausted. Experiments have included screening antifatigue effect on animals, but applications have not been generally established. Effects of drugs on psychological fatigue as seen in man can hardly be inferred from tests on animals. Even physiological effe...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1964
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.84.6_493